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1 : A disease of adults, characterized by a diffuse rigidity and hardness of the skin.

2 : The stony corals; the Madreporaria.

(2) words is found which contain scleroderma in our database

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1 : Scleroderma


A disease of adults, characterized by a diffuse rigidity and hardness of the skin.

2 : Sclerodermata

n. pl.

The stony corals; the Madreporaria.

This word scleroderma uses (11) total characters with white space

This word scleroderma uses (11) total characters with white out space

This word scleroderma uses 9 unique characters: A C D E L M O R S

Number of all permutations npr for scleroderma word is (362880)

Number of all combination ncr for scleroderma word is (362880)

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From Wikipedia

A type of localized scleroderma known as morphea
Usual onsetMiddle age[1]
TypesLocalized, systemic scleroderma[2]
Risk factorsFamily history, certain genetic factors, exposure to silica[3][4][5]
Diagnostic methodBased on symptoms, skin biopsy, blood tests[6]
Similar conditionsMixed connective tissue disease, systemic lupus erythematosus, polymyositis, dermatomyositis[1]
TreatmentSupportive care[1]
MedicationCorticosteroids, methotrexate, non-steroidal anti-inflammatory drugs (NSAIDs)[2]
PrognosisLocalized: Normal life expectancy[7]
Systemic: Decreased life expectancy[3]
Frequency3 per 100,000 per year (systemic)[3]
[edit on Wikidata]

Scleroderma is a group of autoimmune diseases that may result in changes to the skin, blood vessels, muscles, and internal organs.[2][6] The disease can be either localized to the skin or involve other organs in addition to the skin.[2] Symptoms may include areas of thickened skin, stiffness, feeling tired, and poor blood flow to the fingers or toes with cold exposure.[1] One form of the condition, known as CREST syndrome, classically results in calcium deposits, Raynaud's syndrome, esophageal problems, thickening of the skin of the fingers and toes, and areas of small dilated blood vessels.[1]

The cause is unknown.[2] Risk factors include family history, certain genetic factors, and exposure to silica.[3][4][5] The underlying mechanism involves the abnormal growth of connective tissue which is believed to occur as a result of the body's immune system attacking healthy tissues.[6] Diagnosis is typically based on a persons symptoms and may be supported by a skin biopsy or blood tests.[6]

While there is no cure, treatments may improve symptoms.[2] Medications used include corticosteroids, methotrexate, and non-steroidal anti-inflammatory drugs (NSAIDs).[2] Outcomes depend on the extent of disease.[3] Those with localized disease generally have a normal life expectancy.[7] In those with systemic disease typical life expectancy is about 11 years from onset.[3] Death is often due to lung, gastrointestinal, or heart complications.[3]

About 3 per 100,000 people develop the systemic form a year.[3] The condition most often begins in middle age.[1] Women are more often affected than men.[1] Scleroderma was likely first described in 1753 by Carlo Curzio[8] and then well documented in 1842.[9] The term is from the Greek "sklerosis" meaning "hardness" and "derma" meaning "skin".[6]

  1. ^ a b c d e f g "Scleroderma". NORD (National Organization for Rare Disorders). 2007. Archived from the original on 8 September 2016. Retrieved 14 July 2017. 
  2. ^ a b c d e f g h "Scleroderma". GARD. 2017. Archived from the original on 25 January 2017. Retrieved 14 July 2017. 
  3. ^ a b c d e f g h Jameson, Larry (2018). Harrison's Principles of Internal Medicine, 20e (20th ed.). McGraw Hill. p. Chapter 353. 
  4. ^ a b Barnes J, Mayes MD (March 2012). "Epidemiology of systemic sclerosis: incidence, prevalence, survival, risk factors, malignancy, and environmental triggers". Current Opinion in Rheumatology. 24 (2): 165–70. doi:10.1097/BOR.0b013e32834ff2e8. PMID 22269658. 
  5. ^ a b Greenblatt MB, Aliprantis AO (January 2013). "The immune pathogenesis of scleroderma: context is everything" (PDF). Current Rheumatology Reports. 15 (1): 297. doi:10.1007/s11926-012-0297-8. PMC 3539168 Freely accessible. PMID 23288576. Archived (PDF) from the original on 2017-09-08. 
  6. ^ a b c d e "Handout on Health: Scleroderma". NIAMS. August 2016. Archived from the original on 4 July 2017. Retrieved 15 July 2017. 
  7. ^ a b Unsal, Erbil (2006). Current Opinions in Pediatric Rheumatology. Nova Publishers. p. 302. ISBN 9781594548710. Archived from the original on 2017-09-06. 
  8. ^ Mackay, Ian R.; Rose, Noel R. (2006). The Autoimmune Diseases. Academic Press. p. 369. ISBN 9780080454740. 
  9. ^ Firestein, Gary S.; Kelley, William N.; Budd, Ralph C. (2012). Kelley's Textbook of Rheumatology. Elsevier Health Sciences. p. 1366. ISBN 1437717381. Archived from the original on 2017-08-04. 

From Wiktionary


  • 1 English
    • 1.1 Etymology
    • 1.2 Noun
      • 1.2.1 Synonyms
      • 1.2.2 Derived terms
      • 1.2.3 Related terms
      • 1.2.4 Translations


Wikipedia has an article on:


From Ancient Greek σκληρός (sklērós, hard) + New Latin, from Ancient Greek δέρμα (dérma, skin, hide), from δέρω (dérō, to skin, to flay); sclero- +‎ -derma.


scleroderma (plural sclerodermas)

  1. (medicine) A chronic systemic autoimmune disease characterized by hardening the skin or other organs through excessive deposits of collagen.


  • systemic sclerosis
  • scleroderm

Derived terms[edit]

  • sclerodermatous
  • sclerodermoid
  • sclerodermous

Related terms[edit]

  • scleriasis